Boston Children's Hospital
Carl Britto MBBS DPhil is an early career physician scientist studying the immunobiology of pediatric critical care infections. He is a Fellow in Critical Care Medicine in the Division of Critical Care, Department of Anaesthesiology, Critical Care and Pain Medicine at Boston Children's Hospital and a Clinical Fellow of Anesthesia (Critical Care) at Harvard Medical School.
His main academic passion is to decrease infection related morbidity and mortality on a global scale by leveraging a combination of clinical data, gene expression and bioinformatic techniques to guide preventive and therapeutic strategies. He has a wealth of experiences in diverse global health and academic settings.
He was one 5 Indians awarded a Rhodes scholarship to read for a DPhil (PhD) at the University of Oxford in the United Kingdom. He studied the molecular epidemiology of pediatric typhoid in Nepal and India and these data were integral in the WHO pre-qualification process of the Vi-conjugate typhoid vaccine.
He developed a bioinformatic pipeline to analyse host as well as pathogen gene expression simultaneously and also discovered unique gene signatures that predict severe outcomes in Influenza-Staphylococcal pneumonia among children admitted to the PICU. He is currently working on host-pathogen interactions in the context of Group-B-Streptococcal infections with a specific focus on infant meningitis. He has published over 30 peer reviewed papers in high impact journals such as Clinical Infectious Disease, Journal of Infectious Disease, International Journal of Infectious Disease and PLOS Neglected Tropical Disease. He has presented his work at a number of international meetings and has been cited over 1200 times.