Medical ICU Clinical Pharmacy Specialist Cleveland Clinic Cleveland, Ohio
Disclosure(s):
Heather Torbic, BCCCP, BCPS, PharmD: No relevant financial relationship(s) to disclose.
Prompt recognition and response to pathologic bleeding secondary to anticoagulant use requires a level of understanding of pathophysiology and mechanism of action of commonly used medications. This lecture will discuss evidence based reversal of medications such as: warfarin, oral anti-Xa inhibitors (DOACS - apixaban, rivaroxaban, etc.), subcutaneous anti-Xa inhibitors (enoxaparin), direct thrombin inhibitors (argatroban, bivalirudin). The use of plasma, prothrombin complex concentrates and specific antidotes (andexanet alfa) will be discussed, reviewed with risks and benefits of each.
