Can We Improve Outcomes in Pediatric ECMO With Clinical Research?

Sunday, January 21, 2024

3:15 PM – 4:15 PM MT

Location: West-301D

CE: 1.0

Concurrent Session Moderator(s)

Peta Alexander, MBBS, FRACP, FCICM (she/her/hers)

Staff Physician
Boston Children's Hospital
Boston, Massachusetts
Matthew Friedman, MD (he/him/his)

Riley Hospital for Children Indiana University
Indianapolis, Indiana

Extracorporeal membrane oxygenation (ECMO) has been used to rescue critically ill infants and children for more than 50 years. Despite technological advances and clinical innovations, morbidity and mortality associated with ECMO support in this vulnerable population remain unacceptably high. In this session, speakers will highlight the observational, interventional, and adaptive clinical studies that are under way or being planned, with the goal of improving patient outcomes in pediatric ECMO.

Learning Objectives:

Discuss the challenges of conducting observation and interventional clinical trials in neonatal and pediatric extracorporeal membrane oxygenation (ECMO)
Recognize the networks of investigators contributing to advancement of pediatric ECMO
Identify causes of morbidity, mortality, and poor long-term outcomes in pediatric ECMO
Summarize subject identification, recruitment, randomization, and protocol adherence for the optimal conduct of clinical trials
Analyze the benefits of innovative trial designs aimed at accelerating knowledge acquisition to improve clinical care of vulnerable populations

Presentations:

Can We Use Biomarkers to Better Understand Neurologic Injury in Pediatric ECMO?
Does the Timing of ECMO Cannulation Modify Patient Outcomes in Children Supported With ECMO for Respiratory Failure?
Chasing the Dream of Equipoise: Design and Execution Challenges of Multicenter Trial Design in Pediatric ECMO
Decreasing Red Cell Exposure by Aligning RBC Transfusion to Patient Physiology During Pediatric ECMO