Assistant Professor of Medicine
Perelman School of Medicine, University of Pennsylvania
Dr. Christina HW Brotman is an Assistant Professor in Nephrology and clinical epidemiologist at the University of Pennsylvania whose primary research interests are in the areas of acute kidney injury and kidney replacement therapies. She completed her medical degree at the University of Washington, internal medicine residency traiing at the University of California San Francisco, and both her nephrology fellowship and Master of Science in Clinical Epidemiology at the University of Pennsylvania. She has a background in biomedical engineering and mathematics, which has fueled her focus on improving advanced dialysis techniques. Her research has involved the study of alternative biomarkers for estimating kidney function and use of machine learning algorithms for prediction of acute kidney injury following noncardiac surgery. Her present work involves leveraging advanced optical techniques to quantify plasma refilling and examine how plasma refilling relates to hemodynamic stability during hemodialysis. Dr. Brotman is currently the principal investigator of a K23 grant funded by the National Institute of Diabetes Digestive and Kidney Diseases and leads projects using several concurrent optical monitoring techniques to examine how fluid removal during hemodialysis impacts plasma refilling, cardiac function, and cerebral perfusion in hospitalized patients. Her future work aims to better evaluate the physiologic response to hemodialysis and to ultimately develop protocols to guide the management of dialytic therapy in the inpatient setting and minimize the adverse effects of hemodialysis.