Cirrhosis-Associated Immune Dysfunction and Potential for Late Identification of Sepsis

This section will focus on immune dysregulation, altered gut microbiome, and increased risk of sepsis in cirrhosis. It will emphasize the risk of missing early signs of sepsis in cirrhosis because of the lack of compensatory anti-inflammatory response syndrome. Further will describe the increased severity of illness because of the dysregulated immune system and the stage of immune paralysis with subsequent multiorgan dysfunction. The section will spotlight early identification, appropriate choice of antibiotics based on suspected/confirmed resistance patterns, appropriate resuscitative measures, and using prognostic tools to risk-stratify these patients.

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