(1461072-01) Immune Response Transition During Sepsis Progression

Within hours of onset of sepsis, the systemic inflammatory response transitions from a hyper-inflammatory to a persistent low grade pro-inflammatory or hypo-inflammatory and immunosuppressive phase. It is critically important to be aware of these transitions, since the therapeutic options in hyper-inflammatory phase is potentially very different from those during the low grade inflammatory and immunosuppressive phase. The speaker will discuss the evidence for change in immune response in sepsis.

Speaker: Dr. Vidula Vachharajani, Cleveland Clinic Lerner College of Medicine of CWRU is funded by NIH to study sepsis for over a decade. She has been at the forefront of the phase change (from hyper- to hypo-inflammation) during sepsis progression. She will discuss the laboratory and clinical evidence supporting the immune response transition during sepsis progression.