ECMO Program Manager Rhode Island Hospital / Hasbro Children's Hospital Providence
Disclosure(s):
John Priest, RRT-NPS: No relevant financial relationship(s) to disclose.
Modern critical care uses technologies that increase patients' effective circulating volumes of distribution. Continuous renal replacement therapy; extracorporeal life support, including extracorporeal membrane oxygenation; and plasma exchange all may lead to decreased drug concentrations, requiring modifications in dosing, including for such critical agents as antibiotics and sedatives. This session will review the mechanisms through which these systems impact medication dosing and strategies for clinicians to optimize that dosing.
Learning Objectives:
Describe the impact of renal replacement therapies on drug pharmacokinetics and dosing
Identify the causes of altered drug pharmacokinetics in patients receiving extracorporeal life support
Recognize the effects of plasma exchange on commonly used medications in the ICU
